Overview of Mendelian Randomization Analysis
نویسندگان
چکیده
منابع مشابه
Mendelian Randomization Causal Analysis Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
متن کاملGWAS-based Mendelian Randomization Path Analysis
GMRP can perform analyses of Mendelian randomization (MR),correlation, path of causal variables onto disease of interest and SNP annotation analysis. MR includes SNP selection with given criteria and regression analysis of causal variables on the disease to generate beta values of causal variables on the disease. Using the beta vectors, GMRP performs correlation and path analyses to construct p...
متن کامل5. Mendelian randomization
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization, the random assortment of genes from parents to offspring that occurs during gamete formation and conception provides one method for assessing the causal nature of so...
متن کاملPleiotropy-robust Mendelian randomization.
Background The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of ge...
متن کاملMendelian randomization in family data
The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques. We present an approach to instrumental variable estimation that is useful in family data and is robust to the use of weak instruments...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Rheumatic Diseases
سال: 2020
ISSN: 2093-940X,2233-4718
DOI: 10.4078/jrd.2020.27.4.241